Octet-Defying Lab

Simple questions, profound impact

—YKLab

Carbon obeys the octet rule — a fundamental principle in chemistry.
Can this rule be broken to create stable carbon species with fewer than eight valence electrons?


In our lab, we challenge the octet rule, to make octet-defying carbon species by design.
These organic molecules can mimic the behaviour of transition metals. Hence, we seek to harness them as powerful transition metal surrogates, opening new possibilities to a green and sustainable future.

  • YKLab's first group dinner!

    1 December 2025

    Our first group dinner held at the iconic Marina Bay Sands! Welcome to Singapore! 🇸🇬

  • Welcome Tessa Wahl!

    6 Mar 2026

    We welcome Tessa who is joining us from Germany for her Master’s Thesis funded by the Erasmus+ study abroad programme!

  • Meeting with Prof. Richmond Sarpong!

    25 February 2026

    Prof. Richmond Sarpong from UC Berkeley visited NUS! Ying Kai and Richmond had an insightful discussion about carbenes in his office! What a cool guy doing cool chemistry!

  • National Research Foundation Singapore

    Dr. Ying Kai Loh awarded NRF Fellowship Grant!

    Ying Kai has been awarded S$3.25 million National Research Foundation (NRF) Fellowship from Singapore to conduct his research at NUS Chemistry!

  • YKLab welcomes the year of the horse!

    13 February 2026

    We enjoyed tasty dumplings (sweet and savoury) at Din Tai Fung!

  • Meeting with Prof. Manabu Abe!

    5 January 2026

    Prof. Manabu Abe from Hiroshima University visited NUS for the Asian Core Programme (ACP) Lectureship! Ying Kai and Abe-san discussed about octet-defying species (from carbenes to radicals) in his office! Truly humbled!

  • Dr. Ying Kai Loh presented at the Asian Core Programme (ACP) Lectureship Award Symposium held at NUS!

    6 January 2026

    Ying Kai presented his research “From carbene to new octet-defying species and back”!

  • Meeting with Prof. Jin-Quan Yu!

    21 January 2026

    Prof. Jin-Quan Yu from Scripps Research visited NUS for the Chemistry Distinguished Lectureship. Ying Kai and Jin-Quan discussed chemistry (from carbenes to C⎻H activation) in his office! What an honour!

  • Dr. Ying Kai Loh presented at Pacifichem 2025 in Honolulu!

    16 December 2025

    Ying Kai’s first conference presentation since joining NUS as Assistant Professor! Aloha! 🤙🏼

  • YKLab welcomes postdoctoral fellow Dr. Chris Price from the UK!

    24 November 2025

    We welcome Chris which completes our postdoc trio! We enjoyed local delights at Great Nanyang!

  • YKLab welcomes postdoctoral fellows Dr. Lucas Torres from Canada and Dr. Jinghang Shen from China!

    19 November 2025

    Ying Kai, Lucas and Jinghang enjoyed a beautiful evening at Jypsy overlooking the iconic Marina Bay Sands!

  • YKLab welcomes graduate student Zhouyuan Wang from Peking University!

    5 August 2025

    Zhouyuan joins us with the NUS Dean’s Graduate Fellowship! Congratulations!

  • Dr. Ying Kai Loh is officially starting at NUS today!

    17 July 2025

    Office: S9-13-01C
    Lab: S9-13-11B

  • National University of Singapore Logo

    Dr. Ying Kai Loh appointed NUS Presidential Young Professor!

    Ying Kai has been appointed as Assistant Professor in the Department of Chemistry under the NUS Presidential Young Professorship starting 17 July 2025!

  • Ying Kai Loh publishes a Crystalline Secondary Carbon Radical in Nature Synthesis!

    Dr. Ying Kai Loh publishes a Crystalline Secondary Carbon Radical in Nature Synthesis!

    02 May 2024

    Ying Kai isolated the first secondary carbon radical which is stable at room temperature!

  • Doubly Oxidized Carbene named as C&EN’s molecules of the year!

    Doubly Oxidized Carbene named as C&EN’s molecules of the year!

    18 December 2023

    The Doubly Oxidized Carbene was picked by C&EN to be among the six coolest molecules in 2023, and featured in C&EN’s Year in Chemistry!

  • Ying Kai Loh publishes a Crystalline Doubly Oxidized Carbene in Nature!

    Dr. Ying Kai Loh publishes a Crystalline Doubly Oxidized Carbene in Nature!

    20 September 2023

    Ying Kai isolated the first doubly oxidized carbene - a new molecular form of carbon with formally four valence electrons!