Octet-Defying Lab

Simple questions, profound impact

—YKLab

Organic molecules obey the octet rule.
Can we break this rule to make species with less than eight valence electrons?


In our lab, we make “octet-defying” organic species by design.
These compounds have unique properties and can perform tasks exclusive to transition metals. Here we harness them as powerful surrogates for transition metals, opening new possibilities to a green and sustainable future.

  • National Research Foundation Singapore

    Ying Kai Loh awarded NRF Fellowship Grant!

    Dr. Ying Kai Loh has been awarded S$3.25 million National Research Foundation (NRF) Fellowship from Singapore to conduct his research at NUS Chemistry!

  • National University of Singapore Logo

    Ying Kai Loh appointed NUS Presidential Young Professor!

    Dr. Ying Kai Loh has been appointed as Assistant Professor in the Department of Chemistry under the NUS Presidential Young Professorship starting 17 July 2025!

  • Ying Kai Loh publishes a Crystalline Secondary Carbon Radical in Nature Synthesis!

    Ying Kai Loh publishes a Crystalline Secondary Carbon Radical in Nature Synthesis!

    02 May 2024

    Dr. Ying Kai Loh isolated the first secondary carbon radical which is stable at room temperature!

  • Doubly Oxidized Carbene named as C&EN’s molecules of the year!

    Doubly Oxidized Carbene named as C&EN’s molecules of the year!

    18 Dec 2023

    The Doubly Oxidized Carbene was picked by C&EN to be among the six coolest molecules in 2023, and featured in C&EN’s Year in Chemistry!

  • Ying Kai Loh publishes a Crystalline Doubly Oxidized Carbene in Nature!

    Ying Kai Loh publishes a Crystalline Doubly Oxidized Carbene in Nature!

    20 Sep 2023

    Dr. Ying Kai Loh isolated the first doubly oxidized carbene - a new molecular form of carbon with formally four valence electrons!